Anticancer Injection

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MITOBULIN- ERIBULIN : INDICATION

Mitobulin a generic version of HALAVEN – Eribulin is indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting .

Mitobulin a generic version of HALAVEN – Eribulin is indicated for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen.

HOW IS MITOBULIN- ERIBULIN GIVEN

•  MITOBULIN- ERIBULIN is given through a vein as an intravenous push or as intravenous infusion over 2 to 5 minutes.

The amount of MITOBULIN- ERIBULIN that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

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Oxaliplatin, sold under the brand name Eloxatin, is a cancer medication used to treat colorectal cancer. Often it is used together with fluorouracil and folinic acid (leucovorin) in advanced cancer. It is given by injection into a vein.

Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell count Other serious side effects include allergic reactions. Use in pregnancy is known to harm the baby. Oxaliplatin is in the platinum-based antineoplastic family of medications. It is believed to work by blocking the duplication of DNA.

Oxaliplatin was patented in 1976 and approved for medical use in 1996. It is on the World Health Organization''s List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 8.74 to 125.43 USD a vial. In the United Kingdom, it costs the NHS 299.50 pounds per 100 mg dose

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Vidaza is specifically indicated for the treatment of the following myelodysplastic syndrome subtypes:

• Refractory anemia
• Refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions)
• Refractory anemia with excess blasts
• Refractory anemia with excess blasts in transformation
• Chronic myelomonocytic leukemia

Vidaza is administered via subcutaneous injection, with a starting dosing regimen of 75 mg/m2 daily for seven days, every four weeks. The dose may be increased to 100 mg/m2 if the initial dose is insufficient and toxicity was manageable.

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Pemmet 500 mg Injection is an anticancer agent which is used in the treatment of lung cancer. It should be used under the supervision of a qualified professional. Close monitoring of kidney function and blood cell count is necessary while receiving this medication.

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HALAVEN can cause serious side effects, including

• Low white blood cell count (neutropenia). This can lead to serious infections that could lead to death. Your health care provider will check your blood cell counts. Call your health care provider right away if you develop fever (temperature above 100.5°F), chills, cough, or burning or pain when you urinate, as any of these can be symptoms of infection
• Numbness, tingling, or pain in your hands or feet (peripheral neuropathy). Peripheral neuropathy is common with HALAVEN and sometimes can be severe. Tell your health care provider if you have new or worsening symptoms of peripheral neuropathy
• Your health care provider may delay or decrease your dose or stop treatment with HALAVEN if you have side effects

Before you receive HALAVEN, tell your health care provider about all of your medical conditions, including if you

• have liver or kidney problems
• have heart problems, including a problem called congenital long QT syndrome
• have low potassium or low magnesium in your blood
• are pregnant or plan to become pregnant. HALAVEN can harm your unborn baby. Tell your health care provider right away if you become pregnant or think you are pregnant during treatment with HALAVEN. Females who are able to become pregnant should use an effective form of birth control during treatment with HALAVEN and for at least 2 weeks after the final dose of HALAVEN and males should use an effective form of birth control when having sex with female partners who are able to become pregnant during treatment with HALAVEN and for 3½ months (14 weeks) after the final dose of HALAVEN
• are breastfeeding or plan to breastfeed. It is not known if HALAVEN passes into your breast milk. Do not breastfeed during treatment with HALAVEN and for 2 weeks after the final dose of HALAVEN

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of HALAVEN?

HALAVEN can cause changes in your heartbeat (called QT prolongation). This can cause irregular heartbeats. Your health care provider may do heart monitoring (electrocardiogram or ECG) or blood tests during your treatment with HALAVEN to check for heart problems.

The most common side effects of HALAVEN in adults with breast cancer include low white blood cell count (neutropenia), low red blood cell count (anemia), weakness or tiredness, hair loss (alopecia), nausea, and constipation.

Your health care provider will do blood tests before and during treatment while you are taking HALAVEN.

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Chemocare.com uses generic names in all descriptions of drugs. Ramucirumab is the generic name for CYRAMZA™. In some cases, health care professionals may use the generic name ramucirumab when referring to the trade drug name CYRAMZA™.

Drug type: Ramucirumab is a monoclonal antibody, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitor. (For more detail, see "How this drug works" section below).

• Treatment of advanced gastric cancer or gastro-esophageal junction adenocarcinoma.
• Non-small cell Lung cancer
• Metastatic Colorectal cancer

Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.

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Xgeva (denosumab) is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. The Xgeva brand of denosumab is used to prevent bone fractures and other skeletal conditions in people with multiple myeloma, and in people with tumors that have spread to the bone.

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Docetaxel (DTX), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer.^[1] This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer.^[2] It may be used by itself or along with other chemotherapy medication.^[1] It is given by slow injection into a vein.^[1]

Common side effects include hair loss, low blood cell counts, numbness, shortness of breath, vomiting, and muscle pains.^[1] Other severe side effects include allergic reactions and future cancers.^[1] Side effects are more common in people with liver problems.^[1] Use during pregnancy may harm the baby.^[1] Docetaxel is in the taxane family of medications.^[3] It works by disrupting the normal function of microtubules and thereby stopping cell division.^[1]

Docetaxel was patented in 1986 and approved for medical use in 1995.^[4] It is on the World Health Organization''s List of Essential Medicines, the most effective and safe medicines needed in a health system.^[5] Docetaxel is available as a generic medication.^[1] 

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Klaricid IV 500 mg is indicated in adults and children 12 years and older.

Klaricid IV 500 mg is indicated whenever parenteral therapy is required for treatment of infections caused by susceptible organisms in the following conditions;

- Lower respiratory tract infections for example, acute and chronic bronchitis, and pneumonia (see section 4.4 and 5.1 regarding Sensitivity Testing).

- Upper respiratory tract infections for example, sinusitis and pharyngitis.

- Skin and soft tissue infections (e.g. folliculitis, cellulitis, erysipelas) (see section 4.4 and 5.1 regarding Sensitivity Testing).

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

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Daratumumab (trade name Darzalex) is an anti-cancer drug. It binds to CD38,^[1] which multiple myeloma cells overexpress.^[2]Daratumumab was originally developed by Genmab, but it is now being jointly developed by Genmab along with the Johnson & Johnson subsidiary Janssen Biotech, which acquired worldwide commercialization rights to the drug from Genmab.^[3]

Daratumumab was given breakthrough therapy drug status in 2013 for multiple myeloma. It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma.^{[4]
Daratumumab can also bind to CD38 present on red blood cells and interfere with routine testing for clinically significant antibodies. Patients will show a panreactive antibody panel, including a positive auto-control, which tends to mask the presence of any clinically significant antibodies. Treatment of the antibody panel cells with dithiothreitol (DTT) and repeating testing will effectively negate the binding of daratumumab to CD38 on the red blood cell surface; however, DTT also inactivates/destroys many antigens on the red blood cell surface by disrupting disulfide bonds. The only antigen system affected that is associated with common, clinically significant antibodies is Kell, making crossmatch testing with K-negative RBCs a reasonable alternative when urgent transfusion is indicated. [12] It is therefore advisable to do a baseline antibody screen and Rh & Kell phenotyping (type and screen) before starting the therapy. If antibody screen is negative, proceed with phenotype matched transfusions during therapy. If antibody screen is positive, give specific antigen negative blood. The incompatibility may persist for up to 6 months after stopping the medicine. Furthermore, blood transfusion centers should be routinely notified when sending such a sample.}

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1. Epithra Injectionis an anthracycline drug used for chemotherapy Similarly to other anthracyclines, Epithra Injection acts by intercalating DNA strands Intercalation results in complex formation which inhibits DNA and RNA synthesis It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects Epithra Injection also generates free radicals that cause cell and DNA damage Epithra Injection is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effectsEpithra Injection has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar, which may account for its faster elimination and reduced toxicity s primarily used against breast and ovarian cancer, gastric cancer, lung cancer, and lymphomas

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Secukinumab injection comes as a prefilled syringe, a dosing pen, and as a powder to be mixed with liquid and injected subcutaneously (under the skin). It is usually injected once every week for the first 5 doses and then once every 4 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use secukinumab injection exactly as directed. Do not inject more or less of it or inject it more often than prescribed by your doctor.

You may receive your first subcutaneous dose of secukinumab injection in your doctor's office. After that, your doctor may allow you to inject secukinumab yourself or have a friend or relative perform the injections. Before you use secukinumab injection yourself the first time, read the manufacturer's information for the patient that comes with the medication. Ask your doctor or pharmacist to show you or the person who will be injecting the medication how to inject it.

Use each syringe or dosing pen only once and inject all the solution in the syringe or pen. Dispose of used syringes and pens in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

If you are using a prefilled syringe or a dosing pen that has been refrigerated, place the syringe or pen on a flat surface without removing the needle cap and allow it warm to room temperature for 15-30 minutes before you are ready to inject the medication. Do not try to warm the medication by heating it in a microwave, placing it in hot water, or through any other method. Use the injection at least 1 hour after taking it out of the refrigerator.

Do not shake a syringe or dosing pen that contains secukinumab.

Always look at secukinumab solution before injecting it. Check that the expiration date has not passed and that the liquid is clear and colorless. The liquid should not contain visible particles. Do not use a syringe or dosing pen if it is cracked or broken, if it is expired, or if the liquid is cloudy or contains large or colored particles.

You can inject secukinumab injection anywhere on the front of your thighs (upper leg), upper outer arms, or abdomen (stomach) except your navel and the area 2 inches (5 centimeters) around it. To reduce the chances of soreness or redness, use a different site for each injection. Do not inject into an area where the skin is tender, bruised, red, or hard or where you have scars or stretch marks.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with secukinumab injection. Read the information carefully and ask your doctor or pharmacist if you have any questions.

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Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells.

Rituximab is used to treat rheumatoid arthritis and can decrease joint pain and swelling. It is also used to treat certain types of blood vessel disease (such as Wegener's granulomatosis, microscopic polyangiitis) and can decrease the swelling of the blood vessels. Rituximab is also used to treat a certain skin condition (pemphigus vulgaris). It helps to reduce the number of skin lesions.

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